目的探讨乳腺鳞状细胞癌临床表现、病理、鉴别诊断及综合治疗方法。方法通过1例乳腺鳞状细胞癌病例进行报告并文献复习。结果本例排除了其他部位肿瘤转移,且乳腺中的肿瘤与乳头及表皮无任何关系,病理结果只有鳞癌细胞巢的浸润,结合免疫组化结果,本例可确诊为乳腺鳞状细胞癌。结论乳腺鳞状细胞癌确诊须靠组织学诊断,并排除乳腺器官内、身体其他脏器或组织来源的鳞状细胞癌及其他类型的乳腺癌。治疗及预后争议较多,应根据肿瘤TNM分期决定治疗方案,首选手术治疗,术后放化疗。 Objective To investigate the clinical manifestations, pathology, differential diagnosis and comprehensive treatment of breast squamous cell carcinoma of the breast. Methods A case of breast squamous cell carcinoma was reported and reviewed. Results This case excluded the tumor metastasis in other sites, and the tumor in the breast had no relationship with the papilla and the epidermis. The pathological result was only infiltration of the squamous cell nests. Combined with the immunohistochemical results, this case was diagnosed as breast squamous cell carcinoma. Conclusion The diagnosis of breast squamous cell carcinoma depends on histological diagnosis, and excludes squamous cell carcinoma and other types of breast cancer from other organs or tissues in the mammary gland. More controversial treatment and prognosis, TNM staging should be based on tumor treatment options, the preferred surgical treatment, postoperative radiotherapy and chemotherapy.