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本文探讨了￣（１４）Ｃ－５－基愈创木酚钠在大鼠体内的吸收、分布和排泄规律。大鼠灌胃后，￣（１４）Ｃ－５－硝基愈创木酚钠易经胃肠道吸收，血液中的毒物浓度在１．８１ｈ达高峰（Ｃｍａｘ＝１０７．３８ｍｇ／Ｌ），并以中等速度消除，毒一时曲线经拟合符合一室模型。静脉注射染毒的毒一时曲线为二室模型，瞬时血液中毒物浓度达７０．７９ｍｇ／Ｌ，以中等速度分布全身，消除缓慢。￣（１４）Ｃ－５－硝基愈创木酚钠在组织中分布广泛，以肝、肾中含量最高，可通过血脑屏障和血辜屏障。肾为主要排泄器官，从尿中排出的￣（１４）Ｃ－５－硝基愈创木酚钠占染毒剂量的３４．４４％。￣（１４）Ｃ－５－硝基愈创木酚钠在大鼠体内的蓄积性较小。
This article discussed the absorption, distribution and excretion of ~ (14) C-5-guaiac sodium in rats. After intragastric administration, ~ (14) C-5-nitro-guaiacol sodium is easily absorbed in the gastrointestinal tract and the concentration of the poison in the blood reaches a peak at 1.81h (Cmax = 107.38mg / L) Eliminated at moderate speed, the poisonous moment curve was fitted to fit the one-compartment model. Intravenous poisoning poison moment curve for the two-compartment model, the instantaneous blood poisoning concentration of 70.79mg / L, the distribution of the body at a moderate speed, the elimination of slow. ¯ (14) C-5-nitro guaiacol sodium is widely distributed in tissues, with the highest levels in liver and kidney, and can pass the blood-brain barrier and blood-gua-screen. Kidney as the main excretory organ, discharged from the urine ~ (14) C-5-nitro guaiacol sodium accounted for 34.44% of the dose. ¯ (14) C-5-nitro guaiacol sodium in rats less accumulation.