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胶体给药统主要供注射用,口服易被胃肠道内皮细胞摄取,可使不吸收药物能为机体摄取,或可减少肝脏的首过作用。1.1聚甲基丙烯酸毫微粒的体内分布研究了用 r 射线激发或用化学激发缩聚制得的聚甲基丙稀酸毫微粒在体内分布的情况。Kreuter 等氏研究聚2—~(14)C 甲基丙烯酸甲醋毫微粒,在静注30min.后,约60%分布在肝,22%在肺,1.2%在脾。在肾和胃肠道分别为0.44%和1.7%。早期在小肠中出现~(14)C—放射性活度,表
Colloidal drug delivery system for injection, oral easily absorbed by the gastrointestinal tract endothelial cells, can not absorb drugs for the body uptake, or reduce the first pass of the liver. 1.1 In vivo distribution of polymethacrylic acid nanoparticles The distribution of polymethylacrylic acid nanoparticles made by r-ray excitation or chemical excitation polycondensation was investigated in vivo. Kreuter et al. Studied poly 2- (14) C-methylmethacrylate nanoparticles about 60% distributed in the liver, 22% in the lung, and 1.2% in the spleen after 30 minutes of instillation. In the kidney and gastrointestinal tract were 0.44% and 1.7%. Early in the small intestine appeared ~ (14) C- radioactivity, the table