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目的:利用60Co-γ射线辐照对超微弱发光特性的影响,建立简便、快捷的辐照中药颗粒制剂检测方法。方法:2种中药颗粒(小儿泻立停颗粒和板蓝根颗粒)样品分别经剂量率为1.0 kGy.h-1,剂量为0、0.5、1、3、5、7和9 kGy的60Co-γ射线辐照处理,用发光检测仪对样品的超微弱发光特性进行动态检测,样品量为0.05 g,测量时间为50 s(前25 s是在干燥状态下进行,在25 s时注入检测液)。结果:干燥情况下,辐照与未辐照样品超微弱发光强度测定值变化不大,但在检测过程中加入检测液后辐照与未辐照中药颗粒制剂超微弱发光特性有显著性差异,且发光强度呈现出较明显的辐照剂量效应。辐照样品在室温下保存120 d,超微弱发光强度随时间虽有变化,但仍处于与对照组呈显著差异的水平。结论:利用超微弱发光技术可简便、快捷、有效地鉴别中药颗粒制剂是否经辐照处理。
OBJECTIVE: To establish a simple and rapid method for the determination of granules in irradiated Chinese medicine by using the effects of 60Co-γ-ray irradiation on the ultraweak luminescence properties. Methods: The samples of two kinds of traditional Chinese medicine granules (Liriolizhixue granule and Banlangen granule) were respectively irradiated by 60Co-γ ray with dose rates of 1.0 kGy.h-1, 0,0.5,1,3,5,7 and 9 kGy Under irradiation condition, the ultra-weak luminescence characteristics of the sample were detected dynamically with a luminescence detector. The sample volume was 0.05 g and the measurement time was 50 s (the first 25 s was in a dry state and the test liquid was injected at 25 s). Results: Under the dry conditions, the measured value of ultraweak luminescence intensity of irradiated and non-irradiated samples did not change much. However, there was a significant difference between ultra-weak luminescence properties of irradiated and non-irradiated traditional Chinese medicine granule formulations after adding the test solution during the detection. And the luminous intensity showed a more obvious radiation dose effect. Irradiated samples were stored at room temperature for 120 days. Although the ultraweak luminescence intensity changed with time, it was still at a significantly different level from the control group. Conclusion: The use of ultra-weak luminescence technology can be easily, quickly and effectively identify whether the Chinese medicine granules by irradiation.