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目的评价金龙胶囊联合化疗治疗局部晚期非小细胞肺癌的疗效。方法80例局部晚期非小细胞肺癌患者被分为实验组和对照组,其中实验组接受NP方案化疗,同时口服金龙胶囊。对照组仅接受同样方案化疗。结果治疗组CR3例,PR19例,NC14例,PD4例,有效率55%;对照组CR0例,PR18例,NC17例,PD5例,有效率45%,两组比较有显著性差异(P<0.05)。治疗组化疗后白细胞降低发生率及严重程度明显低于对照组,两者比较有显著性差异(P<0.05)。同时,治疗组化疗期间恶心、呕吐发生率及严重程度也明显低于对照组,两者比较有显著性差异(P<0.05)。结论金龙胶囊联合化疗治疗局部晚期非小细胞肺癌具有一定协同作用,尤其是对化疗药物具有明显的减毒作用,不仅能够减轻化疗后白细胞降低,而且还能明显减轻化疗所引起的消化道反应。
Objective To evaluate the curative effect of Jinlong Capsule combined with chemotherapy on locally advanced non-small cell lung cancer. Methods 80 patients with locally advanced non-small cell lung cancer were divided into experimental group and control group. The experimental group received NP regimen and oral Jinlong Capsule. The control group received only the same regimen chemotherapy. Results CR3, PR14, NC14 and PD4 in the treatment group were 55% effective; CR0 cases, PR18 cases, NC17 cases and PD5 cases in the control group had an effective rate of 45% (P <0.05) ). The incidence and severity of leukopenia after chemotherapy in the treatment group were significantly lower than those in the control group, with significant difference (P <0.05). At the same time, the incidence and severity of nausea and vomiting in the treatment group were also significantly lower than those in the control group (P <0.05). Conclusion Jinlong Capsule combined with chemotherapy for the treatment of locally advanced non-small cell lung cancer has a synergistic effect, especially for chemotherapeutic drugs. It not only can reduce leukopenia after chemotherapy, but also significantly reduce the gastrointestinal reaction caused by chemotherapy.