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Objective:To evaluate the short-term effects of neoadjuvant chemotherapy with pingyangmycin(PYM)in the treat-ment of laryngeal squamous cell carcinoma.Methods:24 cases of laryngeal squamous cell carcinoma were treated with PYM before the operation,and the surgeries were undergone within one week after neoadjuvant chemotherapy.PCNA,p53,Bcl-2 and CD44v6 were detected in the specimens of tumor,retreated tumor and normal tissue using immunohistochemical methods.Results:Apoptosis could be detected more often in specimens with tumor and retreated tumor after chemotherapy than that before.The expression of PCNA,p53,Bcl-2 and CD44v6 in tumor tissue after neoadjuvant chemotherapy with PYM was weaker than that before the chemotherapy.There was significant difference in the positive ratio of PCNA,p53,Bcl-2 and CD44v6 be-tween retreated tumor and tumor.Conclusion:After neoadjuvant chemotherapy with PYM,a large number of tumor cells died.The amplification and metastasis of tumor were suppressed by neoadjuvant chemotherapy with PYM.
Objective: To evaluate the short-term effects of neoadjuvant chemotherapy with pingyangmycin (PYM) in the treat-ment of laryngeal squamous cell carcinoma. Methods: 24 cases of laryngeal squamous cell carcinoma were treated with PYM before the operation, and the surgeries were undergone within one week after neoadjuvant chemotherapy. PCNA, p53, Bcl-2 and CD44v6 were detected in the specimens of tumor, retreated tumor and normal tissue using immunohistochemical methods. Results: Apoptosis could be detected more often in specimens with tumor and retreated tumor after chemotherapy than that before. Expression of PCNA, p53, Bcl-2 and CD44v6 in tumor tissue after neoadjuvant chemotherapy with PYM was weaker than that before the chemotherapy. Here was a significant difference in the positive ratio of PCNA, p53, Bcl-2 and CD44v6 be-tween retreated tumor and tumor. Conlusion: After neoadjuvant chemotherapy with PYM, a large number of tumor cells died. amplification and metastasis of tumor were suppressed by neoadjuvant chemotherapy with PYM.