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作者用流感病毒亚单位疫苗和白细胞介素 12 ( IL- 12 )同时进行粘膜接种以分析 IL-12在粘膜表面的佐剂作用。 实验以 BALB/c小鼠为模型 ,于第 0、14、2 8天鼻内接种 2 5μl含 1μg流感病毒( H1N1)亚单位疫苗的磷酸盐缓冲盐水( PBS) ( PBS- H1N1) ,该疫苗由从流感病毒A/PR8/3
The authors performed mucosal injections simultaneously with the influenza virus subunit vaccine and interleukin 12 (IL-12) to analyze the adjuvant effect of IL-12 on mucosal surfaces. Experiment BALB / c mice were modeled and intranasally inoculated with 25 μl of phosphate buffered saline (PBS) (PBS-H1N1) containing 1 μg of influenza virus (H1N1) subunit vaccine on days 0, From the influenza virus A / PR8 / 3