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妊娠是子宫和成熟的囊胚之间复杂的相互作用的结果[1]。随着对滋养细胞研究的深入,发现母胎免疫是发生在母胎之间的免疫对话,且贯穿整个妊娠过程[2]。作为半同种移植物的胎儿,在母体内安然成长至足月,得益于母胎之间的免疫耐受。母胎界面的胎儿面主要由滋养细胞组成,其起源于上皮细胞,是唯一与母体免疫系统直接接触的胎儿细胞,主要分泌β类趋化因子参与蜕膜免疫细胞的募集。
Pregnancy is the result of a complex interaction between the uterus and the mature blastocyst [1]. With the deepening of research on trophoblast cells, it was found that the immunization of the mother’s fetus is an immune dialogue that occurs between the mother’s fetuses and throughout the pregnancy process [2]. As a semi-allograft fetus, the safe growth in the mother to full-term, due to the immune tolerance between mother and fetus. Maternal fetal interface fetal surface is mainly composed of trophoblast cells, which originated in the epithelial cells, is the only direct contact with the maternal immune system of fetal cells, the main secretion of β-type chemokines involved in the recruitment of decidual immune cells.