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目的:探讨促性腺激素释放激素激动药曲普瑞林联合腹腔镜治疗轻度子宫内膜异位症(EM)合并不孕的疗效。方法:轻度EM合并不孕患者50例随机分为观察组和对照组各25例。观察组腹腔镜保守治疗后联合注射曲普瑞林,对照组仅采用腹腔镜保守治疗,比较两组临床疗效及雌二醇(E2),卵泡刺激素(FSH)和黄体生成素(LH)等血清性激素水平变化。结果:治疗后,两组血清性激素水平均显著下降,且观察组血清E2、FSH和LH水平显著低于对照组(P<0.05);观察组治疗有效率92.0%,高于对照组84.0%,不良反应低于对照组,但差异无统计学意义(P>0.05)。结论:腹腔镜保守治疗后联合注射曲普瑞林治疗轻度EM合并不孕疗效显著,不良反应少。
Objective: To investigate the efficacy of gypsrellin combined with laparoscopy in the treatment of mild endometriosis (EM) combined with infertility. Methods: 50 patients with mild EM complicated with infertility were randomly divided into observation group and control group, 25 cases each. The observation group received laparoscopic conservative treatment of triptorelin injection, the control group only laparoscopic conservative treatment, the clinical efficacy and estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH), etc. were compared Serum sex hormone levels change. Results: The levels of serum sex hormones decreased significantly in both groups after treatment, and the levels of E2, FSH and LH in the observation group were significantly lower than those in the control group (P <0.05). The effective rate of the observation group was 92.0%, higher than that of the control group 84.0% Adverse reactions were lower than the control group, but the difference was not statistically significant (P> 0.05). Conclusion: Laparoscopic conservative treatment combined with triptorelin treatment of mild EM with infertility significant effect, less adverse reactions.