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本文观察12例严重慢性充血性心力衰竭的病人(心功能为Ⅲ和Ⅳ级),经用洋地黄及利尿药治疗无效,后改用口服哌唑嗪(prazosin,PZ)3～20mg/d治疗的效果。其中6例为冠心病,3例为充血性心肌病,2例为心脏瓣膜病,1例为冠心病伴主动脉瓣关闭不全。结果 PZ 口服治疗严重慢性充血性心力衰竭,对缓解呼吸困难、改善疲劳及增加运动耐置有显著效果,其中4例心功能由Ⅳ级恢复至Ⅱ级,另4例由Ⅳ级恢复至Ⅲ级,1例由Ⅲ级恢复至Ⅱ级,2例无变
In this paper, we observed 12 patients with severe chronic congestive heart failure (cardiac function Ⅲ and Ⅳ grade), after treatment with digitalis and diuretic invalid, then switch to oral prazosin (PZ) 3 ~ 20mg / d treatment Effect. Of these, 6 were coronary heart disease, 3 were congestive cardiomyopathy, 2 were valvular heart disease, and 1 was coronary heart disease with aortic valve insufficiency. Results PZ oral treatment of severe chronic congestive heart failure, to ease breathing difficulties, improve fatigue and increase exercise tolerance have a significant effect, of which 4 cases of cardiac function recovered from grade Ⅳ to grade Ⅱ, the other 4 cases recovered from grade Ⅳ to grade Ⅲ , 1 case recovered from grade Ⅲ to grade Ⅱ, 2 cases had no change