雷诺氏征(Raynaud’s Phenomenon,以下简称 RP)的主要病理生理是指(趾)血流减少,其原因为灌注压降低,血液粘滞性增加或指(趾)动脉管腔狭窄造成。而血液粘滞性增加可因血浆纤维蛋白增多,血小扳聚集增强或红细胞变形能力降低引起,在这些改变中,以指(趾)动脉狭窄最常见;包括病理性(结构性)管腔狭窄,或功能性血管痉挛,两者亦可同时存在。管腔狭窄是硬皮病患者的明显标志,血管壁的内外膜呈纤维化,管腔内有少量纤维蛋白渗出,这些 The main pathophysiology of Raynaud’s Phenomenon (RP) is the reduced blood flow to the pharynx due to decreased perfusion pressure, increased blood viscosity, or stenosis of the arterial arteries. Increased blood viscosity may result from increased plasma fibrin, enhanced platelet aggregation, or reduced erythrocyte deformability, among which are the most common stenosis of the digits; including pathological (structural) stenosis , Or functional vasospasm, the two can also exist. Stenosis is an obvious hallmark of patients with scleroderma, the inner and outer membranes of the vessel wall are fibrillating and there is a small amount of fibrin exudation in the lumen, which