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目的:探讨胎盘多肽联合抗结核药物应用于肺结核活动期的临床疗效及联合用药后的不良反应发生率.方法将本院180例初治痰菌阳性、且胸片上有斑片阴影或是结核空洞,或是播散病灶的患者分成两组.治疗组90例,在给予常规抗结核药物基础上给予胎盘多肽注射液,4 ml/日;对照组90例,给予常规抗结核药物治疗90例.结果治疗后治疗组和对照组的结核杆菌转阴率为97.8%和76.6%(P<0.01),病灶吸收好转率为97.8%和77.7%(P<0.01),治疗二个月后症状缓解率为95.6%和30.3%(P<0.001).肝损害发生率为5.6%和30.0%(P<0.001),皮疹发生率为3.3%和13.3%(P<0.05).两种治疗方法疗效对比具有统计学差异.结论肺结核活动期使用胎盘多胎注射液联合抗结核药物加速痰涂转阴,更加快速地改善症状、缩短抗结核疗程并减少不良反应的发生,从而增加患者的依从性、减少肺结核的复发和耐药的发生. “,”Objection To investigate the curative effect and the incidence of adverse reaction of piacenta polypeptide injection combined with ani-tuberculosis drug on the treatment of active pulmonary tuberculosis. Method Atotal of 180 sputum positive patients with patchy opacities shadow in chest radiograph or lesions dissemination were equally and randomly divided into single-agent and combined groups.Patients in combined group received anti-tuberculosis drug in combination with placenta polypeptide injection 4ml/day.Those in single-agent group only received anti-tuberculosis.Results After treatment,the sputum negative conversion rate of treatment and control group were 97.8% and 76.6% separately(P〈0.01).Focuts absorpticn rates were 97.8% and 76.6% separately(P〈0.01).The symptoms remission rates were 95.6% and 30.3% separately(P〈0.001),The incidences of liver damage were 5.6% and 30.0% separately(P〈0.001).The incidences of rash were 3.3% and 13.3% separately(P〈0.05).