论文部分内容阅读
目的观察结直肠癌患者手术后经4个化疗周期外周静脉血淋巴细胞P170蛋白的表达及其意义。方法用单克隆抗体免疫荧光法和流式细胞术检测患者外周静脉血淋巴细胞P170蛋白的表达,用统计学原理分析实验数据。结果在化疗药物诱导作用下,外周血P170蛋白的表达呈现上升态势,且差异明显(F=11.492,P<0.01);P170蛋白含量受化疗药物诱导的时间而升高。结论化疗药物可以诱导机体产生获得性多药耐药,并随药物诱导时间延续而越发显著。
Objective To observe the expression of P170 protein in peripheral blood lymphocytes after 4 cycles of chemotherapy in patients with colorectal cancer and its significance. Methods The expression of P170 protein in peripheral blood lymphocytes was detected by immunofluorescence and flow cytometry. The experimental data were analyzed by statistical principle. Results The expression of P170 protein in peripheral blood showed an upward trend under the induction of chemotherapeutic drugs (F = 11.492, P <0.01). The content of P170 protein increased with time induced by chemotherapeutics. Conclusions Chemotherapy drugs can induce acquired multidrug resistance in the body, and become more and more obvious with the prolongation of drug induction time.