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青霉烷砜为-β-内酰胺酶抑制剂,本文报道用国产高效液相色谱仪进行青霉烷砜在家兔中的药动学研究。用ODS-C18作固定相, 98％5mM磷酸钠缓冲液为流动相;青霉烷砜的最低检出值为0.4μg;平均回收率为89.36％,一日内测定精密度CV=3.10％,三日内精密度CV为6.70％。青霉烷砜的药动学过程属二室模型,家兔体内平均t~(1/2)β为0.94h。
Penicillin sulfone is -β-lactamase inhibitor, reported in this paper by domestic high performance liquid chromatography penicillin sulfone pharmacokinetics in rabbits. With ODS-C18 as stationary phase and 98% 5mM sodium phosphate buffer as mobile phase. The detection limit of penicillin-sulfone was 0.4μg. The average recovery was 89.36%. The intra-day precision was CV = 3.10% The intraday precision CV was 6.70%. Penicillin sulfone pharmacokinetics is a two-compartment model, the average rabbit t ~ (1/2) β was 0.94h.