论文部分内容阅读
胰岛素样生长因子－Ｉ（ＩＧＦ－Ｉ）是一种在调节神经生长方面起重要作用的生物活性物质。它通过激活有丝分裂蛋白激酶促进神经细胞树突和轴突的生长。缺氧缺血时脑组织ＩＧＦ－Ｉ水平增高而血浆ＩＧＦ－Ｉ水平下降。ＩＧＦ－Ｉ通过降低脑血管阻力、阻止钙通道开放、减少一氧化氮含量等途径来减轻缺氧缺血对脑组织的损害。本文就ＩＧＦ－Ｉ在神经组织生长发育中的作用，脑内的分布，缺氧缺血脑损伤时ＩＧＦ－Ｉ水平变化和作用机理，及其应用前景作一综述。
Insulin-like growth factor-I (IGF-I) is a biologically active substance that plays an important role in the regulation of nerve growth. It promotes the growth of dendrites and axons in nerve cells by activating mitotic protein kinases. Hypoxia-ischemia brain IGF-I levels increased while plasma IGF-I levels decreased. IGF-I reduces brain damage by reducing cerebral vascular resistance, preventing calcium channels from opening and reducing nitric oxide levels. This article reviews the role of IGF-I in the growth and development of nerve tissue, the distribution in the brain, IGF-I levels and mechanism of action in hypoxic-ischemic brain damage and its application prospects.