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目的研究嫌色细胞肾细胞癌的临床病理特点及诊断要点。方法分析9例嫌色细胞肾细胞癌临床病理组织学特征和免疫表型特征,结合文献进行分析。结果 9例嫌色细胞肾细胞癌组织结构排列主呈实性片状及腺泡状,由嫌色细胞(Ⅰ型)及嗜酸细胞(Ⅱ型)构成,细胞边界清,似植物细胞。特殊染色肿瘤细胞Hale胶体铁染色均阳性。免疫表型:AE1/AE3、EMA、CD117、E-cadherin、CK7、CDl0阳性,Vimentin均不表达,Ki-67指数低。结论嫌色细胞肾细胞癌预后较好,其诊断需结合病理组织学特征和特殊染色、免疫组化表型综合分析。
Objective To investigate the clinicopathological features and diagnosis of chromophobe renal cell carcinoma. Methods The clinicopathological features and immunophenotypic features of 9 cases of chromophobe renal cell carcinoma were analyzed, and the literature was analyzed. Results The structures of 9 cases of chromophobe renal cell carcinoma were mainly arranged in the form of flaky and acinar cells. They consisted of chromophobe cells (type Ⅰ) and eosinophils (type Ⅱ) with clear cell boundary and similar plant cells. Specially stained Hale colloid iron staining of tumor cells was positive. Immunophenotype: AE1 / AE3, EMA, CD117, E-cadherin, CK7, CD10 positive, Vimentin were not expressed, Ki-67 index is low. Conclusions Chophoretic renal cell carcinoma has a good prognosis, and its diagnosis should be combined with histopathological features and special staining, immunohistochemistry phenotype comprehensive analysis.