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目的:探讨不同病理亚型肺神经内分泌肿瘤(BP-NETs)的临床病理特征及n 18F-脱氧葡萄糖(FDG)PET/CT影像表现的差异。n 方法:回顾性分析2013年1月至2018年5月间在河南省人民医院经病理学确诊的280例BP-NETs患者(男196例，女84例，中位年龄58岁)的临床病理资料及PET/CT显像结果。从年龄、性别、有无吸烟史、肿瘤位置、肿瘤大小、细胞增殖核抗原Ki-67阳性指数、甲状腺转录因子-1(TTF-1)、突触素(Syn)、嗜铬素A(CgA)、CD56、n 18F-FDG摄取、淋巴结转移、远处转移等方面比较典型类癌(TC)、不典型类癌(AC)、小细胞肺癌(SCLC)和大细胞神经内分泌癌(LCNEC)患者的差异。采用单因素方差分析、n χ2检验、Fisher确切概率法和Kruskal-Wallis秩和检验分析数据。n 结果:TC(59例)、AC(21例)、SCLC(184例)和LCNEC(16例)4组患者的年龄、吸烟史、肿瘤大小及位置、细胞增殖核抗原Ki-67阳性指数、CgA、CD56、TTF-1、最大标准摄取值(SUVn max)、TNM分期的差异有统计学意义(n F值：2.067、3.358，n H值：17.749～22.351，均n P<0.05)。SCLC组肿瘤最大[5.5(3.0，6.8) cm]，中央型所占比例最高(85.3%，157/184)，更易出现淋巴结转移；LCNEC组年龄最大[(66±16)岁]，有吸烟史者最多(14/16)，周围型所占比例最高(12/16)。SCLC组(95.7%, 176/184)与LCNEC组(15/16)的CD56多呈阳性表达，TC组和AC组的CgA、TTF-1阳性表达率高[96.6%(57/59)、93.2%(55/59)和95.2%(20/21)、90.5%(19/21)]。4组患者的细胞增殖核抗原Ki-67阳性指数及SUVn max均为SCLC组最高，TC组最低。n 结论:不同病理亚型的BP-NETs患者的临床病理特征及n 18F-FDG PET/CT影像表现存在一定差异，分析这些差异可能有助于更好地认识各种亚型不同的特性。n “,”Objective:To investigate the clinicopathological characteristics and n 18F-fluorodeoxyglucose (FDG) PET/CT imaging features of bronchopulmonary neuroendocrine tumors(BP-NETs) with different pathological subtypes.n Methods:From January 2013 to May 2018, 280 patients (196 males, 84 females, median age 58 years) with BP-NETs proved by pathology in Henan Provincial People′s Hospital were retrospectively analyzed. Age, gender, smoking history, the location and size of tumor, Ki-67 positive index, thyroid transcription factor-1 (TTF-1), synaptophysin (Syn), chromogranin-A (CgA), CD56, maximum standardized uptake value (SUVn max), lymph node metastasis and distant metastasis were compared among 4 pathological subtypes of BP-NETs, including typical carcinoid (TC), atypical carcinoid (AC), small cell lung carcinoma (SCLC) and large cell neuroendocrine carcinoma (LCNEC). One-way analysis of variance, n χ2 test, Fisher exact test and Kruskal-Wallis rank sum test were used for data analysis.n Results:There were significant differences in age, smoking history, tumor size and location, Ki-67 positive index, CgA, CD56, TTF-1, SUVn max and TNM stage among TC(n n=59), AC(n n=21), SCLC(n n=184) and LCNEC (n n=16) groups (n F values: 2.067, 3.358, n H values: 17.749-22.351, all n P<0.05). SCLC had the largest tumor size (5.5(3.0, 6.8) cm) and the highest proportion of central type (85.3%, 157/184), and were more prone to lymph node metastasis. LCNEC had the oldest age ((66±16) years), the largest proportion of smoking history (14/16) and peripheral type (12/16). CD56 in SCLC (95.7%, 176/184) and LCNEC(15/16) mostly showed positive expression, while the positive expression rates of CgA and TTF-1 were higher in TC and AC (96.6%(57/59), 93.2%(55/59) and 95.2%(20/21), 90.5%(19/21), respectively). The Ki-67 positive index and SUVn max of the four subtypes were significantly different, with the highest in SCLC group and the lowest in TC group.n Conclusion:Different pathological subtypes of BP-NETs manifest different clinicopathological features and imaging presentation on n 18F-FDG PET/CT, which are useful for understanding their characteristics.n