本文报道了6种非离子型表面活性剂对地高辛直肠吸收作用的评价。作者拟定了6个栓剂处方。每个栓剂含地高辛0.9 mg。所用基质除可可豆脂外,分别加入5％PGMS、GMS、SML、SFAE-15、SFAE-11及吐温60。栓剂长为26mm,直径为8.5mm,重量约为1g。测其熔点、溶出时间和硬度(见下表)。在直肠给药后于0、0.5、1.5、3.0、4.5、7.5和10.0小时采取血样(1.0～1.5ml),将血样离心倾取血浆并立即冰冻。然后,以 This article reports the evaluation of six non-ionic surfactants for digoxin rectal absorption. The author drew up six suppository prescriptions. Each suppository contains digoxin 0.9 mg. The substrates used were 5% PGMS, GMS, SML, SFAE-15, SFAE-11 and Tween 60, respectively, in addition to cocoa butter. Suppository length 26mm, diameter 8.5mm, weighs about 1g. Measured melting point, dissolution time and hardness (see table below). Blood samples (1.0-1.5 ml) were taken at 0, 0.5, 1.5, 3.0, 4.5, 7.5 and 10.0 hours after rectal administration, and the blood samples were centrifuged to decoct plasma and immediately frozen. Then, with