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目的:观察乳腺癌患者术后长期服用三苯氧胺对子宫内膜病变的影响。方法:回顾性分析2002年1月至2004年6月166例乳腺癌患者手术后临床资料。其中102例为雌孕激素受体阳性者,并接受三苯氧胺内分泌治疗作为研究组;其余64例为雌孕激素受体阴性者,未接受三苯氧胺治疗作为对照组。所有患者定期复查阴道超声,发现子宫内膜病变可疑者予宫腔镜检查和诊刮活检术。结果:研究组子宫内膜病变发生率为41.18%(42/102),对照组子宫内膜病变发生率为12.50%(8/64),组间差异有统计学意义(P<0.01)。结论:长期服用三苯氧胺可增加乳腺癌患者术后子宫内膜病变发生率。
Objective: To observe the effect of long-term administration of tamoxifen on endometrial lesions in patients with breast cancer. Methods: The clinical data of 166 cases of breast cancer after operation from January 2002 to June 2004 were retrospectively analyzed. Among them, 102 were estrogen and progesterone receptor positive and received tamoxifen endocrine therapy as the study group; the remaining 64 patients were estrogen and progesterone receptor negative, did not receive tamoxifen as a control group. All patients regularly review vaginal ultrasound and found that suspected endometrial lesions to hysteroscopy and curettage biopsy. Results: The incidence of endometrial lesions in study group was 41.18% (42/102), while the incidence of endometrial lesions in control group was 12.50% (8/64). The difference between the two groups was statistically significant (P <0.01). Conclusion: Long-term use of tamoxifen can increase the incidence of postoperative endometrial lesions in breast cancer patients.