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目的探讨超声造影在肝细胞癌(HCC)和肝局灶性结节增生(FNH)鉴别诊断中的价值。方法选取2012年1月1日至2014年1月1日期间笔者所在医院收治的23例HCC患者和23例肝FNH患者,术前均行超声造影检查,对2组患者的超声造影结果进行对比分析。结果 HCC组造影剂到达时间为(3.8±1.9)s,明显长于肝FNH组的(2.3±1.4)s;达峰时间为(21.8±11.9)s,显著短于肝FNH组的(35.3±14.8)s;峰值强度为(28.8±3.1)d B,显著高于肝FNH组的(22.3±7.9)d B,其差异均有统计学意义(P<0.05)。HCC组患者超声造影诊断的敏感度、特异度、准确性分别为91.3%(21/23)、87.0%(20/23)和95.7%(22/23),肝FHN组患者超声造影诊断的敏感度、特异度、准确性分别为87.0%(20/23)、91.3%(21/23)和91.3%(21/23),2组间比较其差异均无统计学意义(P>0.05)。结论超声造影在HCC和肝FNH的鉴别诊断中具有十分重要的应用价值,可在临床推广应用。
Objective To investigate the value of contrast-enhanced ultrasound in the differential diagnosis of hepatocellular carcinoma (HCC) and focal nodular hyperplasia (FNH). Methods Twenty-three patients with HCC and 23 patients with hepatic FNH who were admitted to our hospital from January 1, 2012 to January 1, 2014 were enrolled in this study. All patients underwent contrast-enhanced ultrasound before operation. Contrast contrast echocardiography analysis. Results The arrival time of contrast medium in HCC group was (3.8 ± 1.9) s, which was significantly longer than that in hepatic FNH group (2.3 ± 1.4) s; the peak time was (21.8 ± 11.9) s, which was significantly shorter than that in hepatic FNH group (35.3 ± 14.8) ) s; the peak intensity was (28.8 ± 3.1) d B, which was significantly higher than that of the liver FNH group (22.3 ± 7.9) d B, the difference was statistically significant (P <0.05). The sensitivity, specificity and accuracy of contrast-enhanced ultrasound in patients with HCC were 91.3% (21/23), 87.0% (20/23) and 95.7% (22/23), respectively. The sensitivity of contrast-enhanced ultrasound in liver FHN patients Degree, specificity and accuracy were 87.0% (20/23), 91.3% (21/23) and 91.3% (21/23), respectively. There was no significant difference between the two groups (P> 0.05). Conclusion Contrast-enhanced ultrasound in the differential diagnosis of HCC and liver FNH has a very important value in the clinical application.