【摘 要】
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Primary liver cancer is the third most common cause of cancer-related deaths worldwide, with a particularly high incidence in Asian countries. Hepatocellular ca
【机 构】
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Center for Infectious Diseases, Kobe University Graduate School of Medicine, Japan“,”Department of G
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Primary liver cancer is the third most common cause of cancer-related deaths worldwide, with a particularly high incidence in Asian countries. Hepatocellular carcinoma (HCC) accounts for 85-90％ of primary liver cancers, and is responsible for approximately 660,000 deaths worldwide each year (1). Hepatitis B virus (HBV) is the most common cause of infectious liver diseases. About 400 million people suffer from chronic HBV infection worldwide, and approximately 60％ of HCC cases each year are related to chronic HBV infection (2). It has been suggested that viral factors (e.g., HBV-DNA levels, genotypes, and genomic mutations), host factors (e.g., age, sex, race, and immune status), and unhealthy lifestyles might contribute to the progression of liver diseases (3).
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