本工作以小鼠为对象研究了脑 Ca~(2+)水平与吗啡及电针镇痛的相互关系。脑室内注射杆菌肽和亮-脑啡肽能增强电针镇痛,后者可被腹腔注射 Ca~(2+)对抗。用多巴胺受体激动剂阿朴吗啡和拮抗剂氟派啶预处理并不改变 Ca~(2+)对电针镇痛的对抗作用,这表示脑内多巴胺类似不直接参与 Ca~(2+)对抗电针镇痛的作用。Ca~(2+)对抗电针镇痛和吗啡镇痛的时程十分相似。所有的结果表明,吗啡镇痛与电针镇痛的机理很可能是相同的。 In this study, we investigated the relationship between brain Ca 2+ level and morphine and electroacupuncture analgesia in mice. Intracerebroventricular administration of bacitracin and enkephalin enhances electroacupuncture analgesia, which can be intraperitoneally injected with Ca 2+ antagonists. Pretreatment with dopamine agonist apomorphine and the antagonist fluopicolon did not alter the antagonistic effect of Ca 2+ on electroacupuncture analgesia, suggesting that intracerebral dopamine does not directly participate in Ca 2+ Against electroacupuncture analgesia. The duration of Ca ~ (2+) resistance to electroacupuncture and morphine analgesia is very similar. All results show that the mechanisms of morphine analgesia and electroacupuncture analgesia are likely to be the same.