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用无环核苷类似物(BW B759u)治疗10例接受骨髓移植后经活检证实为巨细胞病毒性肺炎的患者,4天后血及尿中的病毒转阴,呼吸道分泌物中的病毒平均在治疗8天后消失。但尽管有如上的抗病毒效果,10例肺炎患者中存活者仅1例。通过治疗前后对肺组织的病毒定量培养,肯定BW B759u有确实的抗病毒作用,治疗后病毒滴度平均下降超过99.99％。血中药物水平的峰值及谷值分别超过50及10μmol/L的3例
Treatment of 10 patients with cytomegalovirus pneumonia confirmed by biopsy after treatment with an acyclic nucleoside analogue (BW B759u) turned negative after 4 days in the blood and urine of the urine, with an average of the virus in the respiratory secretions Disappear after 8 days However, despite the above antiviral effects, only 10 of the 10 patients with pneumonia survived. Through the quantitative treatment of the virus in the lung tissue before and after treatment, it is confirmed that BW B759u has a definite anti-virus effect, and the average virus titer dropped by more than 99.99% after treatment. Blood levels of drugs in the peak and trough were more than 50 and 10μmol / L in 3 cases