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1977年起作者用免疫刺激和抗病毒药物异丙肌甙(Isoprinosine)治疗急性病毒性脑炎共27例。13例为坏死性急性脑炎(NAE)。10例为局灶性或假性局灶性,主要是单侧性脑炎,3例为多灶性和双侧性脑炎伴局限于基底部脑室的水肿和颞-额叶底部或颞-枕-顶叶部坏死性病损。7例 NAE 因疱疹病毒所致。此外14例急性弥散性病毒性脑炎患者有断层诊断的弥漫性或多灶性病变而无固定性 NAE,有不同程度的自发性缓解倾向。5例病情严重,9例病情轻,为淋巴细胞浸润的脑膜脑炎或脑脊液γ球蛋白增高的脑炎。
In 1977, the authors treated 27 cases of acute viral encephalitis with immunostimulant and antiviral drug Isoprinosine. Thirteen cases were necrotizing acute encephalitis (NAE). Ten cases were focal or pseudo-focal, mainly unilateral encephalitis, three cases were multifocal and bilateral encephalitis with edema confined to basal ventricles and temporal or frontotemporal or temporal- Pillow - parietal necrotic lesions. Seven cases of NAE due to herpes virus. In addition, 14 cases of patients with acute disseminated viral encephalitis have diffuse or multifocal lesions of the diagnosis of non-fixed NAE, with varying degrees of spontaneous remission. Five patients were severely ill and nine had mild disease with lymphocytic infiltration of meningoencephalitis or elevated cerebrospinal fluid gamma-globulin.