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目的:为临床合理使用肺必清片治疗咳嗽、咳痰、哮喘等呼吸系统疾病提供可靠的实验依据。方法:采用整体动物实验法与离体气管法。结果:肺必清可显著减少氨水所致小鼠的咳嗽次数;显著增加大鼠气管的痰液引流量和小鼠气道腔的酚红排出量;显著延长组织胺与氯化乙酰胆碱对豚鼠引喘的潜伏期;明显地对抗组织胺与乙酰胆碱所致的豚鼠离体气管收缩,松弛气管平滑肌。结论:肺必清具有显著的镇咳、祛痰、平喘作用。
Objective: To provide a reliable experimental basis for the clinical rational use of lung must clear tablets in the treatment of respiratory diseases such as cough, expectoration, asthma. Methods: The whole animal experiment and isolated tracheal method. Results: Feizhiqing can significantly reduce the number of cough caused by ammonia-induced mice; significantly increase the amount of sputum in the trachea of rats and the amount of phenol red excretion in the airway of mice; significantly prolong the effect of histamine and acetylcholine on the guinea pig Asthma latency; significantly antagonized histamine and acetylcholine induced guinea pig tracheal contraction, tracheal smooth muscle relaxation. Conclusion: Pulmonary clear have significant antitussive, expectorant, antiasthmatic effect.