对于长期服用非甾体类消炎药(NSAIDs)的类风湿性关节炎病人,上消化道溃疡出血是贫血的一个重要原因。然而仅45%的患者有上消化道损害,其余原因不明,胃肠可能还存在其它出血部位。动物实验和类风湿性关节炎的临床研究表明服用NSAIAs后可发生小肠溃疡,肠渗透性测定和标记的同位素扫描证实 Bleeding of upper gastrointestinal ulcers is a major cause of anemia in rheumatoid arthritis patients who have been taking NSAIDs for a long time. However, only 45% of patients have upper gastrointestinal damage, the remaining causes unknown, gastrointestinal may also exist other bleeding sites. Clinical studies in animal experiments and rheumatoid arthritis have shown that small intestinal ulcers can occur following the administration of NSAIAs, confirmation of intestinal permeability assays, and isotope labeling of markers