作者认为以丙炔醇(Ⅰ)为原料合成二氨基嘧啶(Ⅲ)的方法是最具有实际意义的。其反应如下: 但应用于生产情况,则存在某些困难,特别是分离中间体丙炔醛(Ⅱ)一步,丙炔醛对粘膜有刺激性,易燃,并于久貯后易起聚合作用。作者利用在有氧化剂存在的情况下,使在氧 The author thinks that the method of synthesizing diaminopyrimidine (Ⅲ) from propargyl alcohol (Ⅰ) is the most practical method. The reaction is as follows: However, there are some difficulties when applied to the production, especially the step of separating the intermediate propargyl aldehyde (II). Propynol is irritant and flammable to mucous membrane and can easily polymerize after long storage . The authors make use of oxygen in the presence of an oxidizing agent