目的探讨剖宫产围手术期应用抗菌药物预防感染的有效、合理的用药方案。方法选择2011年1月—2012年2月在永康市妇幼保健院行剖宫产的产妇2126例,随机分为A、B、C 3组,分别给予不同的给药疗程,A组于术中断脐后静脉应用头孢唑啉2.0 g;B组术中断脐后静脉应用头孢唑啉2.0 g,术后继续使用头孢唑啉2.0 g静滴,2次/d,共48 h;C组术中断脐后静脉应用头孢唑啉2.0 g,术后继续使用头孢唑啉2.0 g静滴,2次/d,共72h。比较3组的临床疗效和经济学指标。结果 3组孕妇切口感染的发生率、术后最高体温均无明显差别(P>0.05);A组西药费较B、C组下降(P<0.05),术后住院天数方面较B、C组明显缩短(P<0.05)。结论剖宫产术中钳夹脐带后单次使用头孢唑林2.0 g静滴预防感染疗效确切,方便经济,值得推广。 Objective To investigate the effective and rational drug regimen of antimicrobial agents for preventing infection during cesarean section perioperative period. Methods 2126 maternal women who underwent cesarean section from January 2011 to February 2012 in Yongkang MCH hospital were randomly divided into A, B and C groups, Cefazolin 2.0 g after umbilical vein application; cefazolin 2.0 g after venous umbilical vein was interrupted in group B, cefazolin 2.0 g intravenously, 2 times / d for 48 hours after operation; Post-cefazolin 2.0 g, cefazolin 2.0 g intravenous infusion, 2 times / d, a total of 72h. The clinical efficacy and economic indicators of the three groups were compared. Results The incidence of incision infection and postoperative maximal body temperature in the three groups showed no significant difference (P> 0.05). The western medicine cost in group A was lower than that in group B and C (P <0.05) Significantly shortened (P <0.05). Conclusion Cesarean section after the umbilical cord clamping single use of cefazolin 2.0 g intravenous infusion of infection prevention effect is accurate, convenient and economical, it is worth promoting.