目的 分析临床药师药物干预对抗生素使用状况的影响?方法 本次研究140例患者均为本院2018年1月至2019年8月接收，所有患者均接受临床药师药学干预，邀请相关专家为临床药师展开培训，详细为其讲解抗生素应用方法?感染控制知识?抗生素滥用情况等，加深临床药师对于各种抗生素的了解，对抗菌药物展开分级处理?在为患者应用抗生素之前，先为其展开病原菌药敏试验，选取适宜的抗生素，临床药师需要参与患者的查房以及临床会诊中，提升抗生素合理应用情况?对比干预前?干预后1个月抗生素使用状况?使用费用和使用不合理性?结果 在抗“,”Objective To analyze the influence of drug intervention by clinical pharmacists on antibiotic use. Methods This study 140 patients were in our hospital from January 2018 to August 2019， all patients were accepted intervention of clinical pharmacists pharmacy， invite relevant experts for the training of clinical pharmacists， detailed interpretation of the antibiotic application methods， for its knowledge of infection control， antibiotics abuse， etc.， deepen the understanding of clinical pharmacists for a variety of antibiotics， hierarchical treatment should be carried out for antibiotics. Before antibiotics are applied to patients， pathogen drug sensitivity tests should be carried out to select appropriate antibiotics. Clinical pharmacists should participate in patients\' ward rounds and clinical consultations to improve the rational application of antibiotics. The status， cost and irrationality of antibiotic use before and one month after intervention were compared. Results The cost of antibiotic use was lower after intervention than before， the difference was statistically significant (P0.05). The utilization rate of single antibiotics was higher after intervention than before， while the utilization rate of triple antibiotics was lower after intervention than before， the difference was statistically significant (P<0.05). The incidence of irrational antibiotic use was lower after intervention than before， and the difference was statistically significant (P<0.05). Conclusion Pharmaceutical intervention of clinical pharmacists is helpful to reduce the cost of antibiotic use， and can significantly reduce the combined use rate， and ensure the scientific and rational use of antibiotics.