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目的:测定乐口颗粒中小檗碱(Berberine)的含量,作为该制剂的一项质量控制指标,并对其煎提过程中小檗碱的动态进行分析,为工艺改进提供依据。方法:采用HPLC法测定乐口颗粒中小檗碱(Berberine)的含量。结果:乐口颗粒中小檗碱的含量为(1.369±0.051)mg.g-1,回收率为95.9%。结论:HPLC方法快速简便,可用作该制剂质量控制及动态分析的手段。
OBJECTIVE: To determine Berberine content in Lokou granules as a quality control index of the preparation and to analyze the dynamics of berberine in the process of decocting, which can provide the basis for process improvement. Methods: HPLC method was used to determine Berberine content in Lokou granules. Results: The content of berberine in Lokou granules was (1.369 ± 0.051) mg.g-1, the recovery was 95.9%. Conclusion: The HPLC method is rapid and simple and can be used as a means of quality control and dynamic analysis of the preparation.