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金鸡納皮类药物在17世紀即用于医学中,而奎尼丁首先为Van Heyningen氏在1848年发現。1893年对其药理学已有記載。1914年Wenckebach氏应用奎宁治疗伴有心房纤顫的疟疾患者,同时控制了心房纤顫。直到1918年Frey氏发現奎尼丁对心房纤顫的疗效远較奎宁优越。早年对奎尼丁的毒性作用认识不足造成严重意外,故未普過采用。近年由于心电图的广泛应用,血中奎尼丁浓度的测定,对其药理作用有进一步的认识及大量临床資料的积累,使奎尼丁治疗慢性心房
In the 17th century, the quintessential civets were used in medicine, and quinidine was first found in 1848 by Van Heyningen. Its pharmacology has been documented in 1893. In 1914, Wenckebach’s use of quinine in patients with malaria associated with atrial fibrillation controlled at the same time atrial fibrillation. Until 1918 Frey’s discovery of quinidine effect of atrial fibrillation is far superior to quinine. Early understanding of the toxic effects of quinidine caused a serious accident, it is not commonly used. In recent years, due to the widespread use of ECG, blood quinidine concentration determination of its pharmacological effects and further understanding of the accumulation of a large number of clinical data so that quinidine treatment of chronic atria