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为探讨柯萨奇病毒B特异性IgM（CVB－IgM）的病原学意义，应用免疫印迹试验测定112例病毒性心肌炎患儿的CVB－IgM，结果是阳性33例，总阳性率为29．5％；27例正常儿童中阳性者1例，占3．7％，两者比较差异有显著意义（X2=7．813，P＜0．01）。病程小于2个月者阳性率为40％，与病程2～6个月和大于6个月者（阳性率分别为4．55％和13．33％）比较均有显著差异（X2=9．832，P＜0．01和X2=4．921，P＜0．05）。提示在临床上存在心肌炎症或心肌损伤时，测定CVB－IgM具有早期病原学诊断意义。
To investigate the etiological significance of Coxsackievirus B-specific IgM (CVB-IgM), CVB-IgM was measured in 112 children with viral myocarditis using Western blotting, and the results were positive in 33 patients with a total positive rate of 29.5 %; 27 cases of normal children were positive in 1 cases, accounting for 3.7%, the difference was significant (X2 = 7.813, P <0.01). The positive rate was 40% in patients with less than 2 months of disease duration and significant difference (X2 = 9%) when compared with patients with disease duration of 2-6 months and more than 6 months (positive rates were 4.55% and 13.33% respectively). 832, P <0.01 and X2 = 4.921, P <0.05). Prompted the clinical presence of myocardial inflammation or myocardial injury, the determination of CVB-IgM has an early etiological diagnosis.