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目的:了解张掖市手足口病的病原体和流行特征以及发病趋势,为我市手足口病防控提供科学依据。方法:采用实时荧光定量PCR法对手足口病肠道病毒核酸进行检测。结果:2012--2013年张掖市疾控中心检测手足口轻型疑似病例120例,确认人肠道病毒核酸阳性84例,发病高峰位于每年6-8月份;男女性别阳性率无统计学意义(P﹥0.05);发病人群主要为5岁以下儿童,其中又以3岁以下儿童所占比例最大;地域分布以甘州区和民乐县发病率最高,其次是山丹县;检出的病原体主要是EV71、COXA16及其它EV;但两年间型别有交替流行趋势,2012年以COXA16占优势,2013年以EV71占优势。结论:2012-2013年张掖市发生的手足口病发病季节明显;地域分布有差异;发病以5岁儿童为主;主要病原体有EV71、COXA16及其它EV。
Objective: To understand the pathogens and epidemic characteristics of hand-foot-mouth disease in Zhangye city and its trend of onset, and provide a scientific basis for the prevention and control of hand-foot-mouth disease in our city. Methods: The real-time PCR method was used to detect HFMV enteric virus nucleic acid. Results: From 2012 to 2013, Zhangye Municipal CDC detected 120 cases of mild suspected cases of hand, foot and mouth, confirming the positive of human enterovirus nucleic acid in 84 cases and the peak of incidence was in June and August of each year. The positive rate of male and female was not statistically significant (P > 0.05). The incidence was mainly for children under 5 years of age, of which children accounted for the largest proportion of children under 3 years old. The geographical distribution was highest in Ganzhou District and Minle County, followed by Shandan County. The pathogens detected were mainly EV71, COXA16 and other EVs. However, in the past two years, there was a trend of alternating trends. In 2012, COXA16 was predominant and EV71 was predominant in 2013. Conclusion: The incidence of hand-foot-and-mouth disease in Zhangye City between 2012 and 2013 was significant. The geographical distribution was different. The incidence was mainly in children aged 5 years. The main pathogens were EV71, COXA16 and other EVs.