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目的研究安定对产程中产妇的作用，药物透过胎盘屏障及对新生儿的影响。方法选择产程潜伏期或潜伏期延长的住院产妇３０例，静注安定１０ｍｇ，用荧光偏振免疫分析法（ＦＰＩＡ）测定静注后５ｍｉｎ、２ｈ的母血和胎儿娩出时的母血及脐血的药物浓度，并进行新生儿Ａｐｇａｒ评分。结果静注后５ｍｉｎ、２ｈ的母血、胎儿娩出时的母血及脐血的安定浓度依次迅速降低且均低于最低有效浓度（４００ｎｇ／ｍｌ）；新生儿１ｍｉｎ和５ｍｉｎ的Ａｐｇａｒ评分正常（９～１０分）。结论静注１０ｍｇ安定可使产妇疼痛缓解、疲劳减轻、宫缩加强、迅速进入产程。并对母婴均无不良影响。
Objective To study the effects of diazepam on mothers during labor, drug penetration through the placental barrier and neonatal effects. Methods 30 cases of hospitalized women with prolonged latency or prolonged labor were intravenously administered with 10mg intravenous injection. FPI-A was used to determine the levels of maternal blood and umbilical cord blood Drug concentration, and neonatal Apgar score. Results The serum concentrations of maternal blood and umbilical blood at 5 min and 2 h after intravenous injection were decreased rapidly and were lower than the lowest effective concentration (400 ng / ml) respectively. Apgar scores at 1 and 5 min were normal ~ 10 points). Conclusion intravenous 10mg diazepam can relieve the pain of maternal, reduce fatigue, contractions strengthened, quickly into the labor process. And no adverse effects on mother and child.