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地点:乌干达国家结核病治疗中心Mulago医院与协和临床医学研究中心,乌干达,Kampala。 目的:比较感染HIV和未感染HIV的结核病人在标准化短程化疗(SCC)期间的痰结核杆菌定量。 设计:选择14个感染HIV和22个未感染HIV涂阳成年肺结核病人,比较在标准的4药短程化疗的开始以及治疗期间二者的临床特征以及定量痰菌,定量痰菌是按照定量抗酸杆菌(AFB)涂片,菌落形成单位分析以及在BACTEC放射测量性液体系统培养出现阳性结果的时间这3个指标来测量。 结果:肺空洞和肺腺病在两组人群分布不同,前者多见于未感染HIV肺结核病人,而后者多见于感染HIV肺结核病人;两组间开始的人口学特征、临床表现、放射学以及实验室检查结果没有显著性差异。两组间治疗前的痰菌平均数(感染HIV肺结核病人为6.5±0.51 loR_(10)AFB/ml,5.91±0.91 log_(10)cfu/ml以及BACTEC培养出现阳性为1.8±1.7天;未感染HIV肺结核病人为6.32±0.85 log10AFB/ml,5.58±0.68log10cfu/ml以及BACTEC培养出现阳性1.9±1.2天相似。病人通过标准化短程化疗(SCC),两组病人的临床和细菌学反应及其治疗结果无差异。 结论:感染HIV和未感染HIV的成年涂阳结核病人在标准化短程化疗开始以及治疗期间的定量痰菌没有显著性差异。
Location: Mulago Hospital, Uganda National Tuberculosis Center, and Concord Medical Research Center, Kampala, Uganda. Objectives: To compare the quantification of sputum Mycobacterium tuberculosis during normalized short-course chemotherapy (SCC) between HIV-infected and non-HIV-infected TB patients. Design: Select 14 HIV-infected and 22 non-HIV-positive adult tuberculosis patients, compare the clinical features of both at the beginning and the end of standard 4-dose brachytherapy and quantify sputum, Bacillus subtilis (AFB) smear, colony forming unit analysis and time to positive results in BACTEC radiometric liquid culture. Results: The distribution of lung cavity and lung adenosis was different between the two groups. The former was more common in HIV-infected patients than in HIV-infected tuberculosis patients. The latter was more common in HIV-infected TB patients. The demographic characteristics, clinical manifestations, radiology and laboratory There is no significant difference between the test results. The average number of sputum before treatment between the two groups (6.5 ± 0.51 loR_ (10) AFB / ml, 5.91 ± 0.91 log_ (10) cfu / ml for HIV-infected tuberculosis and 1.8 ± 1.7 days for BACTEC culture; Patients with HIV had a similar incidence of 6.32 ± 0.85 log10 AFB / ml, 5.58 ± 0.68 log10 cfu / ml and a positive B 1.9 ± 1.2 days after BACTEC culture.7 Patients were treated with standardized short-course chemotherapy (SCC), clinical and bacteriological responses and treatment outcomes in both groups No difference.Conclusion: There was no significant difference in the quantitative sputum between the infected and non-HIV-infected adult smear-positive tuberculosis patients at the beginning of standardized short-course chemotherapy and during treatment.