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目的:观察胞二磷胆碱在脑梗死和脑出血急性期的疗效,探讨其用药剂量和时机。方法:将急性脑出血和脑梗死病例随机分为两大组,即对照组(常规用药)和治疗组。治疗组加用胞二磷胆碱0.5～1.0g静脉滴注,每日1次,10～14天为一疗程,疗程间隔5～7天,有颅内高压症者在确诊1周后加用。脑梗死治疗组按胞二磷胆碱,日剂量0.5g和1.0g再分为两组,比较其有效率。结果:加用胞二磷胆碱治疗脑梗死显效率极明显高于对照组(P<0.01),脑出血治疗组总有效率高于对照组(P<0.05),治疗脑梗死时加用胞二磷胆碱,日剂量1.0g组比0.5g组疗效好(P<0.05)。结论:加用胞二磷胆碱治疗脑卒中能使疗效提高,不仅对脑梗死有效,对脑出血也有效。脑梗死患者采用1.0g/d胞二磷胆碱剂量疗效较高,并无明显不良反应。
Objective: To observe the effect of citicoline in the acute stage of cerebral infarction and cerebral hemorrhage and to explore the dosage and timing of citicoline. Methods: Acute cerebral hemorrhage and cerebral infarction were randomly divided into two groups, namely control group (conventional treatment) and treatment group. Treatment group plus citicoline 0.5 ~ 1.0g intravenous infusion, 1 day, 10 to 14 days for a course of treatment interval of 5 to 7 days, with intracranial hypertension in the diagnosis of 1 week after the addition . Cerebral infarction treatment group by citicoline, daily dose of 0.5g and 1.0g and then divided into two groups, compared with its efficiency. Results: The addition of citicoline was effective in treating cerebral infarction significantly higher than that in control group (P <0.01). The total effective rate of cerebral hemorrhage treated group was higher than that of control group (P <0.05) Diphosphocholine, daily dose 1.0g group than the 0.5g group curative effect (P <0.05). Conclusion: The addition of citicoline can improve the curative effect of stroke, which is not only effective for cerebral infarction but also effective for cerebral hemorrhage. Patients with cerebral infarction with 1.0g / d citicoline dose higher efficacy, no significant adverse reactions.