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作者研究了美洛西林(Mezlocillin)在老年人体内的药代动力学.12名健康志愿者,年龄为65～86岁,参试前均经过体检、血化学检查、血细胞计数和尿液检查证实为正常,且预先排除对青霉素过敏、严重心血管病及血质不调者.将受试者分为两组,禁食过夜后分别给予美洛西林4g或5g,用生理盐水溶解后加入50ml5%葡萄糖注射液中,静滴30分钟.定期采集血样及尿样,用微生物法测定美洛西林浓度.一周后两组交换用药剂量,按同法进行测定.结果:美洛西林血清浓度的变化符合二室模型,4g和5g剂量组的C_(max)分别为216.6±
The authors studied the pharmacokinetics of mezlocillin in the elderly.12 healthy volunteers, aged 65-86 years, were tested for physical, blood chemistry, and blood tests before taking the test Were normal, and precluded penicillin allergy, severe cardiovascular disease and poor blood quality of the subjects were divided into two groups were fasting overnight were given mezlocillin 4g or 5g, dissolved in saline after adding 50ml5 % Glucose injection, intravenous drip for 30 minutes, blood samples and urine samples were collected regularly, and the concentration of mezlocillin was determined by microbiological method.After a week, the doses of the two groups were measured by the same method.Results: The changes of the concentrations of mezlocillin According to the two-compartment model, the C max values of the 4g and 5g groups were 216.6 ±