患者,男40岁。因周身疼痛、乏力2月于1992年7月4日来院就诊。查体:T36.8℃,贫血貌,胸骨压痛,表浅淋巴结及肝脏均无肿大,脾脏肿大达左肋缘下3.5cm。周围血象示Hb 90g/L,WBC 3.6×10~8/L,N0.76,L0.16,原粒0.08,BPC 80×10~9/L,可见晚幼红细胞,部分成熟红细胞呈泪滴形和豆点状。两侧骼前、骼后4次穿刺均有干抽,涂片见有核细胞少,粒系异常增生,原粒47.5％,呈病理畸形,红系异常增生,原粒47.5％,呈病理畸形,红系及巨核细胞系增生受抑。骨髓活检示骨髓增生减低,粒系异常增生,骨小梁增粗,其间胶原纤维和网状纤维增生取代了正常造血组织。入院诊断:急性粒细胞白血病(M2a)并发骨髓纤维化。给予DA和HOAP各3个疗程,于 Patient, male, 40 years old. Because of whole body pain, fatigue in February on July 4, 1992 to the hospital. Physical examination: T36.8 ℃, anemia appearance, sternal tenderness, superficial lymph nodes and liver no swelling, enlargement of the spleen up to the left costal margin of 3.5cm. Peripheral blood showed Hb 90g / L, WBC 3.6 × 10 ~ 8 / L, N0.76, L0.16, the original particle 0.08, BPC 80 × 10 ~ 9 / L, visible late red blood cells, some of the mature red blood cells were teardrop-shaped And bean punctate. Both sides of the ilium, ilium after four punctures have dry pumping smear, see fewer nucleated cells, abnormal proliferation of granulocyte lineage, 47.5% of the original particles, was pathological deformities, erythroid dysplasia, protoplasm 47.5%, pathological deformity , Erythroid and megakaryocytic hyperplasia suppressed. Bone marrow biopsy showed decreased myeloproliferation, abnormal proliferation of myeloid, trabecular bone thickening, during which collagen fibers and reticular fibrous hyperplasia replaced the normal hematopoietic tissue. Admission diagnosis: Acute myeloid leukemia (M2a) complicated with myelofibrosis. Give DA and HOAP each 3 courses, at