The pharmacokinetics and relative bioavailability were studied in 18 healthy volunteers. A single oral dose of 150 mg irbesartan capsule (test) or tablet (reference) was given to each volunteer according to a randomized 2-way crossover study. The concentrations in plasma were determined by HPLC-UV method. The main parameters of irbesartan capsules were: Cmax: 1. 502± 0. 295 μg/ml,tmax: 1. 44±0. 34 h, t1/2: 20. 21±14. 71 h, AUC0-t: 11. 087t3.443 μg/ml-1·h. The relative bioavailability of capsule to tablet was (101.4±28.9) %. The results of statistical analysis showed that two formulations were hioequivalent.