表面活性物质(surfactant)是一类磷脂化合物,能降低表面张力,是维持正常呼吸功能不可少的物质。既往认为,只有肺泡Ⅱ型细胞才能分泌这类磷脂;但近年来发现,它们也存在于胃粘膜上皮的表面。胃内的表面活性物质究竟有什么功用呢?这是近来很多学者想了解的问题。最近,美国Texas大学医学院Lich-tenberger等发现,胃内的表面活性物质具有细胞保护作用。作者等用1ml 0.6molHCl灌入结扎幽门的大鼠以造成胃粘膜损伤模型,并作了下列观察:(1)如果预先用1ml表面活性物质混悬液注入胃,30min后再注入HCl,可明显减轻HCl引起的胃粘膜坏死和出血;(2)如果在表面活性物质灌胃之前45min于皮下注射消炎痛(5mg/kg)阻断前列腺素(PG)合成,虽然能加重对照组的胃粘膜损伤,但不能阻断表面 Surfactants are phospholipid compounds that lower the surface tension and are essential for maintaining normal respiratory function. In the past that only alveolar type Ⅱ cells can secrete phospholipids; but in recent years found that they also exist in the gastric mucosal epithelium surface. What is the role of the surface active substances in the stomach? This is a question that many scholars recently want to understand. Recently, Lich-tenberger et al. At the University of Texas Medical School found that the intragastric surfactant has a cytoprotective effect. The authors used 1ml 0.6molHCl infused ligation of pylorus rats to cause gastric mucosal injury model and made the following observations: (1) If 1ml surfactant suspension was injected into the stomach in advance, 30min and then injected HCl, can be significantly (2) Inhibition of prostaglandin (PG) synthesis by subcutaneous injection of indomethacin (5 mg / kg) at 45 min prior to gavage of surfactant, while aggravating gastric mucosal injury in the control group , But can not block the surface