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在Ｄ５．８０ｍｍ制式枪弹致伤动物模型上的颌面部，于致伤后２、６、２４、７２ｈ、７ｄ取材，检测组织内ＮＯ的含量，并用ＨＥ和ＮＡＤＰＨ－ｄ染色观察组织形态学变化与一氧化氮合酶（ＮＯＳ）活性的关系。结果发现：伤后组织内ＮＯ含量明显增高，２４ｈ达到高峰，７ｄ维持较低水平；２４～７２ｈ组织呈进行性损伤，组织内可见大量ＮＯＳ阳性细胞，７ｄ组织内修复现象明显，ＮＯＳ阳性细胞明显减少。结果提示：颌面部枪弹伤后组织进行性损伤和修复愈合与Ｌ－精氨酸／ＮＯ途径的激活有关；ＮＯ的大量生成是组织细胞损伤的重要因素之一。
The maxillofacial region of the animal model of D5.80mm gunshot wound was harvested at 2, 6, 24, 72h, 7d after injury. The content of NO in the tissue was detected. The morphological changes of the maxillofacial region were observed by HE and NADPH-d staining And nitric oxide synthase (NOS) activity. The results showed that NO content in injured tissue increased significantly, peaked at 24h and maintained at a low level at 7d, progressive damage was observed at 24 ~ 72h, and a large number of NOS positive cells were observed in the wounds. cut back. The results suggest that the maxillofacial injury of gunshot wounds is associated with the activation of L-arginine / NO pathway; the massive production of NO is one of the important factors of tissue cell injury.