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目的 制订车间空气中玻璃钢粉尘卫生标准。方法 采用现场劳动卫生流行病学调查方法及用玻璃钢粉尘对大鼠肺脏进行致纤维化实验研究 ,观察大鼠全肺干质量和全肺胶原蛋白含量。结果 该粉尘可引起大鼠全肺干质量和全肺胶原蛋白含量增加 (P <0 0 1或P <0 0 5 ) ,且有剂量 反应关系 ,作业工人有“尘肺”样改变。结论 根据动物实验研究和现场劳动卫生学调查结果 ,提出车间空气中玻璃钢粉尘最高容许浓度为 6mg/m3,时间加权平均容许浓度为 3mg/m3。
Objective To develop the workshop air glass fiber dust health standards. Methods The on-site labor hygiene epidemiology survey method and fibrinolysis were used to study the fibrosis of lung in rats. The total lung mass and the content of collagen in the lung were observed. RESULTS: The dust caused an increase in total lung mass and whole lung collagen content in rats (P <0.01 or P <0.05) and a dose-response relationship. The workers also experienced “pneumoconiosis” -like changes. Conclusions According to the results of animal experiments and on-site labor hygiene survey, the maximum allowable concentration of FRP dust in workshop air is 6mg / m3 and the time-weighted average allowable concentration is 3mg / m3.