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目的探讨丹参川芎嗪注射液联合曲克芦丁脑蛋白水解物治疗急性脑梗死患者的临床疗效。方法回顾性选取2011年4月至2013年5月苏州九龙医院神经外科收治的急性脑梗死患者25例,按临床治疗意愿将其分为观察组(13例)和对照组(12例)。对照组患者给予丹参川芎嗪注射液,观察组患者在对照组基础上采用曲克芦丁脑蛋白水解物进行治疗,比较两组患者的临床治疗效果、神经功能缺损评分以及血液学指标。结果观察组患者的总有效明显高于对照组,差异有统计学意义(P<0.05);治疗后10 d、1个月、2个月观察组患者的神经功能缺损评分均明显低于对照组,差异均有统计学意义(均P<0.05);治疗后,观察组患者的血小板凝聚率、纤维蛋白原水平、血细胞比容均明显低于对照组,差异均有统计学意义(均P<0.05)。结论丹参川芎嗪注射液联合曲克芦丁脑蛋白水解物治疗急性脑梗死,能有效改善患者的临床症状及血液循环状况,提高治愈率。
Objective To investigate the clinical effect of ligustrazine injection combined with troxerutin in the treatment of patients with acute cerebral infarction. Methods Twenty - five patients with acute cerebral infarction admitted to Department of Neurosurgery, Kowloon Hospital, Suzhou from April 2011 to May 2013 were retrospectively selected. The patients were divided into observation group (n = 13) and control group (n = 12) according to clinical treatment intention. Patients in the control group were given Salviae Miltiorrhizae ligustrazine injection. The patients in the observation group were treated with troxerutin hydrolyzate on the basis of the control group. The clinical therapeutic effect, neurological deficit score and hematological indexes were compared between the two groups. Results The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). The scores of neurological deficit in the observation group at 10 d, 1 month and 2 months after treatment were significantly lower than those in the control group (All P <0.05). After treatment, the platelet aggregation rate, fibrinogen level and hematocrit in the observation group were significantly lower than those in the control group (all P <0.05), and the differences were statistically significant 0.05). Conclusion Salviae miltiorrhizae ligustrazine injection combined with troxerutin hydrolyzate in the treatment of acute cerebral infarction can effectively improve the clinical symptoms and blood circulation and improve the cure rate.