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通过复制家兔动脉粥样硬化(As)模型,用自制豚鼠抗兔ApoB血清,探讨病变程度不同的各主动脉节段上ApoB的分布及其与Ch沉积量之间的相关性及二者与血浆ApoB之间的相关性。同时还测定了血浆TC、HDL-C及TG水平。实验组主动脉ApoB高于对照组,且弓段>胸段>腹段(P均<0.01),对照组未测出;在病变较严重的节段ApoB与Ch含量呈直线正相关(r弓段=0.860,r胸段=0.737),而病变较轻节段不相关(r腹段=0.467)。血浆ApoB与主动脉ApoB(r=0.895)及Ch(r=0.827)呈高度直线正相关。血浆ApoB与TC的升高不平行,ApoB的上升较TC为稳定。
By replicating atherosclerosis (As) model in rabbits and using homemade guinea pig anti-rabbit ApoB serum, the distribution of ApoB and its correlation with Ch deposition in different aortic segments with different degrees of lesions were investigated. The correlation between plasma ApoB. Plasma TC, HDL-C, and TG levels were also measured. ApoB in the aorta of the experimental group was higher than that of the control group, and the segment of the bow> thoracic> abdominal (P <0.01) was not detected in the control group; there was a positive linear correlation between the ApoB and Ch content in the more severely diseased segment (r bow Segment=0.860,r thoracic segment=0.737), but the lighter segments were not related (r ventral segment=0.467). Plasma ApoB was highly linearly positively correlated with aortic ApoB (r=0.895) and Ch (r=0.827). The increase of plasma ApoB and TC was not parallel, and the increase of ApoB was more stable than that of TC.