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目的:分析IL-6、IL-8和TNF-α水平的变化与急性脑梗死发病、严重程度和进展情况的关系。方法:选取2012-10-2013-06因急性脑梗死入院治疗的患者共100例(观察组),同时选取同期健康体检者96例作为对照组。对比观察组不同时间点与对照组血清白细胞介素6(IL-6)、白细胞介素8(IL-8)、肿瘤坏死因子-α(TNF-α)浓度。对比轻度、中度和重度患者第1天的血清IL-6、IL-8、TNF-α浓度。对比进展性脑梗死和非进展性脑梗死患者第1天的血清IL-6、IL-8、TNF-α浓度。结果:观察组发病第1天、第3天、第7天和第14天的IL-6、IL-8、TNF-α浓度均显著高于对照组(P<0.05);观察组第3天的IL-6、IL-8、TNF-α浓度显著高于第1天,第7天、第14天的IL-6、IL-8、TNF-α浓度则逐渐显著下降(P<0.05)。脑梗死第1天的血清IL-6、IL-8、TNF-α浓度随着脑梗死的程度加重和进展升高,P<0.05。结论:急性脑梗死患者的血清IL-6、IL-8、TNF-α浓度明显升高,且和脑梗死严重程度和进展密切相关,临床检测可有助于诊断及评估急性脑梗死的严重程度。
Objective: To analyze the relationship between the changes of IL-6, IL-8 and TNF-α and the incidence, severity and progression of acute cerebral infarction. Methods: A total of 100 patients (observation group) admitted to hospital from 2012-10-2013-06 due to acute cerebral infarction were enrolled. 96 healthy subjects were selected as control group. The levels of serum IL-6, IL-8 and TNF-α in the observation group were compared with those in the control group at different time points. The levels of serum IL-6, IL-8 and TNF-α on day 1 of mild, moderate and severe patients were compared. The levels of serum IL-6, IL-8 and TNF-α on the first day in patients with progressive cerebral infarction and non-progressive cerebral infarction were compared. Results: The concentrations of IL-6, IL-8 and TNF-α in observation group were significantly higher than those in control group on the 1st, 3rd, 7th and 14th days (P <0.05) The concentrations of IL-6, IL-8 and TNF-αincreased significantly (P <0.05) on the 1st, 7th and 14th days. The levels of IL-6, IL-8 and TNF-α in the first day of cerebral infarction were increased and progressed with the degree of cerebral infarction (P <0.05). CONCLUSIONS: Serum levels of IL-6, IL-8 and TNF-α in patients with acute cerebral infarction are significantly increased, and are closely related to the severity and progress of cerebral infarction. Clinical examination may be helpful in the diagnosis and assessment of the severity of acute cerebral infarction .