最近,日本爱媛大学第二内科的国府达郎教授等成功地合成了一种新型口服肾素抑制剂—ES-6864,该制剂可特异的抑制肾素,而且在酶学方面对肾素也有很高的特异性。又由于它可溶于水,从而解决了一直未能解决的肾素抑制剂消化道吸收问题。首先,在体外探讨了ES-6864的IC_(50)值(50％抑制率)、种属特异性和酶特异位。对来源于人 Recently, Professor Takahara, a government of the second internal medicine department of Ehime University in Japan, successfully synthesized a novel oral renin inhibitor, ES-6864, that inhibits renin specifically and also has an enzymatic effect on renin High specificity. And because it is soluble in water, thus solving the persistent renin inhibitor gastrointestinal absorption problems. First, the ES 5064 values ​​(50% inhibition), species-specific and enzyme-specific positions of ES-6864 were explored in vitro. Right from people