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目的探讨Survivin和E-cadherinherin在非特殊型乳腺浸润性导管癌发生、发展中的作用。方法采用免疫组化法检测Survivin和E-cadherin在120例非特殊型乳腺浸润性导管癌组织(A组)、120例乳腺良性病变组织(B组)及120例乳腺癌旁正常乳腺组织(C组)中的表达情况,分析其与乳腺癌患者临床病理特征的联系以及乳腺癌组织中Survivin和E-cadherin间的相关性。结果 A组Survivin阳性表达率显著高于B组和C组(P<0.05),E-cadherin阳性表达率显著低于B组和C组(P<0.05);Survivin和E-cadherin的阳性表达率与浸润性导管癌患者的临床病理指标中的临床分期、淋巴结癌转移、病理类型有相关性(P<0.05),A组中Survivin和E-cadherin的阳性表达率存在负相关(r=-0.697,P<0.05)。结论 Survivin和E-cadherin的表达在浸润性导管癌中有着重要作用,对评估其恶性程度和预后有重要临床意义。
Objective To investigate the role of Survivin and E-cadherinherin in the occurrence and development of non-specific breast invasive ductal carcinomas. Methods Immunohistochemistry was used to detect the expression of Survivin and E-cadherin in 120 cases of non-specific breast invasive ductal carcinoma (A group), 120 cases of benign breast lesions (B group) and 120 cases of normal breast tissue adjacent to breast cancer (C Group), and to analyze its relationship with the clinicopathological characteristics of breast cancer patients and the correlation between Survivin and E-cadherin in breast cancer tissues. Results The positive rate of Survivin expression in group A was significantly higher than that in group B and C (P <0.05), while the positive expression rate of E-cadherin in group A was significantly lower than that in group B and C (P <0.05). The positive rate of Survivin and E-cadherin (P <0.05). There was a negative correlation between the positive expression rates of Survivin and E-cadherin in group A (r = -0.697 , P <0.05). Conclusion The expression of Survivin and E-cadherin plays an important role in invasive ductal carcinoma, and has important clinical value in assessing the malignant degree and prognosis.