论文部分内容阅读
本文报道了增效脒(piperonyl butoxide)对大鼠致畸作用的研究,所用剂量为0、300和1,000mg/kg体重,每组雌鼠20只,在妊娠第6～15天,经口给药,对照组只给玉米油。于妊娠第20天处死,检查子宫内着床数、吸收数、活胎数、卵巢内黄体数和胎鼠的外观,并观察骨骼和内脏的发育。结果表明,试验组雌鼠均无异常表现,虽然整个妊娠期增重稍差,但给药期间实验组上体重与对照组相似。试验组与对照组的黄体数、着床数、吸收数、胎鼠体重和外观检查,统计上均无显著性差异。两个试验组各有两只异常胎鼠,300mg/kg组的两只分别为
This paper reports the teratogenic effects of piperonyl butoxide in rats at doses of 0, 300 and 1,000 mg / kg body weight with 20 females per group on day 6 to 15 of gestation, Medicine, the control group only to corn oil. On the 20th day of pregnancy, the number of implants in the uterus, the number of abscesses, the number of live births, the number of luteal ovaries and the appearance of fetal rats were examined. The development of bones and viscera was also observed. The results showed that the experimental group of females showed no abnormalities, although the weight gain during pregnancy slightly less, but the experimental group during the administration of body weight similar to the control group. There was no significant difference in luteal number, implantation number, absorption number, fetal rat weight and appearance examination between the experimental group and the control group. Two test groups each had two abnormal fetuses, two of the 300 mg / kg group were respectively