目的：应用颅面联合入路切除侵犯前颅底鼻腔、鼻窦恶性肿瘤术。方法：手术根据肿瘤原发部位、大小及周围侵犯程度进行分型。硬脑膜及前颅底骨缺损，使用带蒂帽状腱膜骨膜瓣及颞肌骨膜瓣进行修补。眼窝及颌面部缺损，使用带血管蒂游离腹直肌皮瓣进行一期眼窝假眼床、颧弓及硬腭重建。结果：２１例患者均采用经颅面联合入路肿瘤整块切除术。术中术野广范，采取修补材料方便，无严重合并症及并发症。结论：该术式适于对侵犯前颅底鼻腔鼻窦恶性肿瘤的切除和一期修复 OBJECTIVE: To apply a craniofacial joint approach to resection of anterior skull base nasal and sinusal malignancy. Methods: Surgery was based on the location of the tumor, size and surrounding invasion. The dura mater and anterior skull base bone defects were repaired using pedicled aponeuroid flaps and diaphragmatic periosteal flaps. For orbital and maxillofacial defects, a vascularized free rectus abdominis myocutaneous flap was used for the reconstruction of a stage orbital false eye bed, zygomatic arch and hard palate. RESULTS: Twenty-one patients underwent total tumor resection with transcranial approach. Wide range of intraoperative operative field, convenient repair materials, no serious complications and complications. Conclusion: This surgical procedure is suitable for resection and primary repair of malignant nasal cavity and sinuses of the anterior skull base