环氧酶 2 (ＣＯＸ 2 )多分布在人的中枢神经系统等部位 ,外周炎症时炎症局部的ＣＯＸ 2表达常增加 ,导致前列腺素 (ＰＧ)释放 ,从而提高外周伤害性感受器的敏感性 ,引起局部痛觉过敏。同时由于背髓神经元的兴奋性增高 ,外周炎症还可引起邻近完好组织的痛觉过敏和肌肉、关节疼 Cyclooxygenase 2 (COX 2) is mainly distributed in the human central nervous system and other parts of the body. Inflammatory peripheral COX 2 expression often increases in peripheral inflammation, resulting in the release of prostaglandin (PG), thereby increasing the sensitivity of peripheral nociceptors and causing Local hyperalgesia. At the same time due to the excitability of the neurons in the dorsal horn increased, peripheral inflammation can also cause pain and hyperalgesia in adjacent intact tissue, joint pain